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Sources of MRI contrast in natural formula and hydrogel formulation of pineapple juice

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Document pages: 12 pages

Abstract: Magnetic resonance imaging (MRI) usually requires the use of contrast agents to improve the visibility of certain tissues and organs, including the gastrointestinal tract. In the latter case, oral drugs can be used instead of intravascular administration. Natural oral contrast agent, if juice, has better taste, tolerance and lower price than artificial contrast agent. We characterized the relaxation curve of pineapple juice to understand the reason for the increase of relaxation rate (and MRI contrast) caused by manganese ion content. In addition, the relaxation curves of pineapple juice in the presence of different amounts of sodium alginate were characterized; Interaction between manganese ion and sodium alginate slws down their reorientation time to some extent, with a subsequent increase in the relaxation rates. The relaxometry profiles were also compared with those of manganese(II) solutions in 50 mmol dm3 sodium acetate solution (same pH of pineapple juice), which revealed sizable differences, mostly in the number of water molecules coordinated to the metal ion, their lifetimes, and in the constant of the Fermi-contact interaction. Finally, the fit of the transverse relaxivity shows that the increased viscosity in the hydrogel formulations can improve significantly the negative contrast of pineapple juice at the magnetic fields relevant for clinical MRI.

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