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Novel gallium (III), germanium (IV) and hafnium (IV) folate complexes and their spectral, thermal decomposition, morphological and biological properties

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Document pages: 12 pages

Abstract: In this study, we describe novel gallium (III), germanium (IV) and hafnium (IV) folate complexes, including their synthesis and analysis. The synthesized folate complexes were also thermally analyzed (TGA) to better examine their thermal degradation and kinetic properties. Folate complexes are highly stable and non spontaneous. Coats – Redfern and Horowitz – Metzger equations are used to determine thermodynamic parameters and describe kinetic properties. These complexes were synthesized by the chemical interaction of folate Drug Ligand (fah2) with gacl3, GeCl4 and hfcl4 metal salts in a neutralization medium at 1 ℃ (molar ratio of  :   2 (metal)  :   ligand). Due to its non electrolyte behavior, the conductivity measurement is low. X-ray powder diffractionn solid powder pattern revealed a semicrystalline nature. In vitro, we screened the synthesized folate chelates for antibacterial and antifungal activities. The inhibition of four bacterial and two fungi pathogens (E. coli, B. subtilis, P. aeruginosa, S. aureus, A. flavus, and Candida albicans) was improved using a folic acid drug relative to the control drug.

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