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Synthesis, characterization and in vitro cytotoxicity of Cu (II) and Fe (III) complexes with asymmetric tetradentate Schiff Base

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Document pages: 10 pages

Abstract: Asymmetric tetradentate Schiff base Fe (III) and Cu (II) complexes were prepared by coordinating some asymmetric tetradentate Schiff base ligands with CuCl2 · 2H2O or FeCl3 · 6H2O. The complexes were characterized by ESI-MS, IR and UV Vis. The spectral data of typical signals are consistent with the proposed molecular formula of the complex. Their cyclic voltammetry studies in acetonitrile solution showed that the reduction processes of Cu (II) Cu (I) and Fe (III) Fe (II) were in the best state (− 1.882 – (−) 1.782   V and at (−) 1.317 – (−) 1.164   v. through in vitro cytotoxicity screening of KB and Hep-G2 human cancer cell lines, the results showed that the almost asymmetric tetradentate Schiff base complex had good cytotoxicityexes bearing the unsymmetrical tetradentate Schiff base ligands with different substituted groups in the salicyl ring indicate different cytotoxicity. The obtained Fe(III) complexes are more cytotoxic than Cu(II) complexes and relative unsymmetric Schiff base ligands.

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