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Antibacterial activity of 2-pyridyl polypyridyl ruthenium (II / III) complexes against non drug resistant and drug resistant bacteria

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Document pages: 11 pages

Abstract: A new hexadentate 2-pyridyl polypyridine ligand (4,4-apos; - (butane-1,4-diacylbis (oxygen)) bis (n, N-bis (pyridin-2-ylmethyl) aniline) (2but) (1) and its corresponding Ru (II III) were synthesized and characterized The ligand was characterized by proton NMR, FTIR and ESI-MS, which showed that the ligand had been successfully synthesized. Ruthenium (II III) was studied by FTIR, UV Vis, elemental analysis, proton NMR, ESI-MS and magnetic susceptibility The complexes were characterized. The analysis of ESI-MS data of the complexes showed that they were successfully synthesized. The empirical formula obtained from the elemental analysis of the complexes also showed thated successful synthesis and relative purity of the complexes. The important functional groups of the ligands could be observed after complexation using FTIR. Magnetic susceptibility data and electronic spectra indicated that both complexes adopt a low spin configuration. The disc diffusion assay was used to test the compounds for antibiotic activity on two bacteria species and their drug-resistant counterparts. The compounds displayed antibiotic activity towards the two non-drug-resistant bacteria. As for the drug-resistant organisms, only [Ru2(2BUT)(DMF)2(DPA)2](BH4)43 and 2, 2-dipyridylamine inhibited the growth of MRSA. Gel electrophoresis DNA cleavage studies showed that the ligands had no DNA cleaving properties while all the complexes denatured the bacterial DNA. Therefore, the complexes may have DNA nuclease activity towards the bacterial genomic material.

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