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S100A8 / A9 molecular complex promotes the migration and invasion of nasopharyngeal carcinoma through p38 MAPK pathway

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Document pages: 11 pages

Abstract: Nasopharyngeal carcinoma (NPC) is a malignant tumor associated with migration and invasion, and its mechanism is unclear. We previously found that as a promising biomarker, the plasma S100A8 A9 levels in patients with nasopharyngeal carcinoma were roughly elevated. However, their expression and potential function in nasopharyngeal carcinoma are still unclear. In this study, we analyzed 49 cases of nasopharyngeal carcinoma and 20 cases of chronic pharyngitis (CP). Immunohistochemical staining was performed in different tissues and statistical analysis was performed by Mann – Whitney U test. Further cross well migration and invasion experiments were conducted to determine the impact of S100A8 A9 on NPC. Our results showed that S100A8 A9 in nasopharyngeal carcinoma was significantly higher than that in CP, which was closely related to the clinical symptoms of nasopharyngeal carcinomages. Intriguingly, exogenous S100A8 A9 protein stimulation could dramatically enhance NPC migration and invasion abilities. In addition, p38 MAPK pathway blockade could diminish the migration and invasion of NPC cells stimulated by S100A8 A9 proteins. The downstream tumor invasion and migration associated proteins (e.g., MMP7) were also elevated in NPC tissues, consistent with S100A8 A9 overexpression. Taken together, our present findings suggest that the secreted soluble inflammatory factors S100A8 A9 might promote cancer migration and invasion via the p38 MAPK signaling pathway along with invasion migration associated proteins overexpression in the tumor microenvironment of NPC. This may shed light on the mechanism understanding of NPC prognosis and provide more novel clues for NPC diagnosis and therapy.

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