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Bioinorganic synthesis of polyrhodanine stabilized Fe3O4 / graphene oxide in microbial supernatant and its anticancer and antibacterial applications

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Document pages: 12 pages

Abstract: Polyrhodanines have been widely used in many fields because of their attractive properties. The effect of polyrhodanine (PR -) based materials on human cells can be considered as a controversial issue, but there are many contradictions. In this study, we focused on the synthesis of graphene oxide modified polyrhodanine Fe3O4 and the effect of Kombucha (KO) supernatant on the results. The overall structure of the synthesized compounds was determined in detail by Fourier transform infrared spectroscopy (FT-IR). In addition, the morphology, magnetic and chemical properties of the compounds were characterized by scanning electron microscopy (SEM), vibrating sample magnetometer (VSM) and energy dispersive X-ray (EDX). Nano materials with antibacterial effect were synthesized to CLSI against four infamous pathogens. Also, the cytotoxic effects of the synthesized compounds on the human liver cancer cell line (Hep-G2) were assessed by MTT assay. Our results showed that Go Fe has the highest average inhibitory effect against Escherichia coli and Pseudomonas aeruginosa, and this compound possesses the least antimicrobial effect on Staphylococcus aureus. Considering the viability percent of cells in the PR GO Fe3O4 compound and comparing it with GO Fe3O4, it can be understood that the toxic effects of polyrhodanine can diminish the metabolic activity of cells at higher concentrations (mostly more than 50 µg mL), and PR Fe3O4 Ko exhibited some promotive effects on cell growth, which enhanced the viability percent to more than 100 . Similarly, the cell viability percent of PR GO Fe3O4 KO compared to PR GO Fe3O4 is much higher, which can be attributed to the presence of kombucha in the compound. Consequently, based on the results, it can be concluded that this novel polyrhodanine-based nanocompound can act as drug carriers due to their low toxic effects and may open a new window on the antibacterial agents.

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