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Therapeutic potential of statins using nanofiber carriers

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Document pages: 10 pages

Abstract: Statins are 3-hydroxy-3-methylglutaryl CoA (HMG CoA) reductase inhibitors widely used in the treatment of hypercholesterolemia. In fact, many studies have shown that these drugs have beneficial effects on a variety of related diseases, including increasing the stability of atherosclerotic plaque, reducing vascular smooth muscle hyperplasia, platelet aggregation, inhibiting vascular inflammation and anabolic effects on bone tissue. Therefore, these drugs are considered to be pleiotropic drugs with different clinical applications, rather than the drugs originally developed for them. Controlled drug delivery is an effective way of drug delivery in tissue engineering. Among different controlled-release preparations, nanofibers are a new, alternative and widely used drug in the United Statesd agent because of their unique properties. These include their sustained release of drug, a high drug-loading capacity, flexible shapes with a high surface-to-volume ratio, and superior porosity. Electrospinning is an economic and a simple method employed to produce nanofibers. In this report, studies related to statin nanofiber applications have been reviewed and their results have been summarized. Four different applications of statin nanofibers have been reported, including bone generation, endothelial stenosis and thrombosis, peripheral nerve injury, and anti-inflammatory action. Studies carried out both in vitro and in vivo showed effectiveness of statins in bone healing, aneurysm, and the healing of sciatic nerve injury. In addition, statins showed apoptosis effects and anti-inflammatory effects, with dose-dependent reduction of IL-6 and dose-independent reduction of TNF-α. Despite these promising results, validation via clinical trials is yet to be performed. The scope of statins in their pleiotropic range of actions is still not completely explored, and studies are still needed to enlighten different useful aspects of such drugs.

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