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Physicochemical study on interference of copper chloride on ceftriaxone antibiotics

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Document pages: 15 pages

Abstract: Nano cucl2.2h2o salt was prepared by ball milling. At different temperatures, the association parameters of bulk and nano CuCl2 salts in H2O were estimated by using fuoss – shedlovsky equation and conductivity method. The association parameters of nano CuCl2 were higher than those of bulk CuCl2 salts. The interaction between cation (Cu2 +) and ligand (ceftriaxone) in H2O was determined by conductivity method. Two stoichiometric complexes 1 2 and 1 1 (M L) are estimated. The order is KF (1 1)   >   KF (1  :   2) and GF (1 2)   >   ∆ (m) (negative value). It shows that the formation of (1 1) complex is better than that of (1 1) complex  :   2). With the increase of temperature, the change of Gibbs free energy is negatively correlated. Antibacterial activity of CF, bulk Cu-CFT complex, and nano-Cu-CFT complex were studied on LB agar by the disc diffusion technique against clinical isolates of gram-negative bacteria (Klebsiella pneumonia and Pseudomonas aeruginosa) and Fungi (Candida albicans). It was observed that (CFT) has a higher zone of inhibition and antibacterial activity than that of bulk and nano-Cu-CFT complexes in Klebsiella pneumonia and Pseudomonas aeruginosa (gram-negative bacteria). The nano-Cu-CFT complex showed a higher clear zone of inhibition and antifungal activity against candida than bulk Cu-CFT complex while the absence of the inhibition zone in CFT, so nano-Cu-CFT complex, can be used as an antifungal drug.

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