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Progress in the detection of antibiotic residues in food by surface enhanced Raman spectroscopy

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Document pages: 16 pages

Abstract: Antibiotics, as veterinary drugs, have made an extremely important contribution to the disease prevention and treatment of animal breeding industry. However, due to the overuse of antibiotics in animal feeding, the accumulation of antibiotics in animal food often occurs, which in turn will cause serious harm to public health when humans eat antibiotics. Antibiotic residues in food have become one of the core issues of global food safety. As a safety measure, rapid and effective analytical methods for detecting these residues must be implemented to prevent contaminated products from reaching consumers. Traditional analytical methods, such as liquid chromatography, liquid chromatography-mass spectrometry and capillary electrophoresis, involve time-consuming sample preparation and complicated operation and require expensive instrumentation. By comparison, surface-enhanced Raman spectroscopy (SERS) has excellent sensitivity and remarkably enhanced target recognition. Thus, SERS has become a promising alternative analytical method for detecting antibiotic residues, as it can provide an ultrasensitive fingerprint spectrum for the rapid and noninvasive detection of trace analytes. In this study, we comprehensively review the recent progress and advances that have been achieved in the use of SERS in antibiotic residue detection. We introduce and discuss the basic principles of SERS. We then present the prospects and challenges in the use of SERS in the detection of antibiotics in food. Finally, we summarize and discuss the current problems and future trends in the detection of antibiotics in food.

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