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Purification and characterization of mitogenic lectin from pathogenic cephalosporins

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Document pages: 6 pages

Abstract: Ophthalmic mycoses caused by infectious fungi are considered a serious problem because they can lead to complete blindness. Cephalosporin is one of several opportunistic fungi related to ocular infection leading to fungal keratitis. A mitogenic lectin has been purified from the mycelium of the fungal cephalosporin, which was isolated from corneal smears of patients with keratitis. Cephalosporin lectin (CSL) is a tetramer   kDa with subunit mass of 14. It can agglutinate human a, B and O erythrocytes. It has higher affinity for mucin than fetal globulin and salivary fetal globulin, but does not bind to monosaccharide, indicating that it has complex sugar specificity. CSL has strong binding with normal cellsthe lectin and its interaction with PBMCs to exhibit mitogenic effect indicate its possible role in adhesion and infection process of Cephalosporium.

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