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Evaluation of serum testosterone, progesterone, semen antisperm antibody and fructose levels in Jordanian men with a history of infertility

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Document pages: 8 pages

Abstract: Due to the biochemical complexity of semen, we tried to study the possible correlation between fructose secreted under the action of androgen and autoimmunity, which may play a role in varicocele related infertility and reduce sperm motility. Semen fructose, antisperm antibodies (ASAS) and blood steroid hormones (testosterone and progesterone) were measured in 66 infertile men with varicocele and 84 infertile men without fertility treatment. Semen analysis was performed by semen fructose biochemical measurement and ASA mixed agglutination reaction (MAR). The levels of serum progesterone and testosterone were determined by competitive chemiluminescence enzyme immunoassay. The average value of serum testosterone was, and  ng dl, progesterone , , and  ng ml, and seminal plasma fructose , , and  mg dl in males with varicocele, without varicocele, and fertile males, respectively. A significant high level of testosterone was observed within varicocele group (). This result showed that testosterone may play a role as an infertility determinant in subjects with varicocele. ASA was detected in 18 (26.47 ) of cases with varicocele, 20 (38.46 ) without varicocele, and in 16 (32.0 ) fertile men. Cases with ASAs associated with low sperm motility morphology. An inverse correlation between sperm-bound antibodies and viscosity has been shown (). ASA showed some significant inverse relations with ages, durations of infertility, and viscosity (). In addition, a significant correlation was observed between ASA positive seminal plasma and testosterone concentration among infertile cases (with or without varicocele) and fertile (). Our results suggest a relationship between testicular steroid hormone levels with autoimmunity and sperm antibodies which influence the motility of ejaculated spermatozoa among Jordanian infertile males.

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