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HSP70 and its molecular role in nervous system diseases

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Document pages: 18 pages

Abstract: Heat shock proteins (HSPs) are a response to many injuries, including stroke, neurodegenerative diseases, epilepsy and trauma. Overexpression of a heat shock protein, especially heat shock protein 70, plays a protective role in several different models of nervous system injury, but it is also related to the harmful effects of some diseases. HSP70 acts as a partner to protect neurons from protein aggregation and toxicity (Parkinson s disease, Alzheimer s disease, polyglutamine disease and amyotrophic lateral sclerosis), protect cells from apoptosis (Parkinson s disease), is a stress marker (temporal lobe epilepsy), protects cells from inflammation (cerebral ischemic injury), and plays an adjuvant role in antigen presentation, And participate in the immune response of autoimmune diseases (multiple sclerosis)s). The worldwide incidence of neurodegenerative diseases is high. As neurodegenerative diseases disproportionately affect older individuals, disease-related morbidity has increased along with the general increase in longevity. An understanding of the underlying mechanisms that lead to neurodegeneration is key to identifying methods of prevention and treatment. Investigators have observed protective effects of HSPs induced by preconditioning, overexpression, or drugs in a variety of models of brain disease. Experimental data suggest that manipulation of the cellular stress response may offer strategies to protect the brain during progression of neurodegenerative disease.

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