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Research progress of articular cartilage tissue engineering hydrogel

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Document pages: 13 pages

Abstract: The treatment of articular cartilage injury is an important task of orthopedic medicine. Hydrogels have the ability to form multifunctional cartilage grafts because they have polymer swelling when immersed in aqueous phase. Polymer hydrogels have physiological expansion and lubrication capabilities, and have the mechanical properties required as a substitute for articular cartilage. The chondrogenic phenotype of these materials can be enhanced by implantation of living cells. Artificial hydrogels made from bio derived and synthetic polymer materials can also be used as scaffolds for tissue engineering. By controlling the degradation curve, stimulating growth factors can be released. To make use of these hydrogels, cartilagelants were formulated in the laboratory to demonstrate the bionic mechanical behaviors of physiological cartilage. This paper discusses developments concerning the use of polymeric hydrogels for substituting injured cartilage tissue and assisting tissue growth. These gels are designed with consideration of their polymeric classification, mechanical strength, manner of biodegradation, limitations of the payload, cellular interaction, amount of cells in the 3D hydrogel, sustained release for the model drug, and the different approaches for incorporation into adjacent organs. This article also summarizes the different advantages, disadvantages, and the future prospects of hydrogels.

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