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Direct Current Auditory Evoked Potentials During Wakefulness, Anesthesia, and Emergence from Anesthesia

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Document pages: 7 pages

Abstract: Direct current auditory evoked potentials (DC-AEPs)are a sensitive indicator of depth of anesthesia in ani-mals. However, they have never been investigated inhumans. To assess the potential usefulness of DC-AEPsas an indicator of anesthesia in humans, we performedan explorative study in which DC-AEPs were recordedduring propofol and methohexital anesthesia in hu-mans.DC-AEPs were recorded via 22 scalp electrodesin 19 volunteers randomly assigned to receive eitherpropofol or methohexital. DC-AEPs were evoked bybinaurally presented 2-s, 60-dB, 800-Hz tones; meas-urementswere taken during awake baseline, anesthesia,and emergence. Statistical analysis included analy-sisof variance and discriminant analysis of dataacquired during these three conditions. About 500 msafter stimulus presentation, DC-AEPs could be ob-served.These potentials were present only during base-lineand emergence—not during anesthesia. Statisticallysignificant differences were found betweenbaseline and anesthesia and between anesthesia andemergence. In conclusion, similar effects, as reported inanimal studies of anesthetics on the DC-AEPs, could beobserved in anesthetized humans. These results dem-onstratethat DC-AEPs are potentially useful in the assessmentof cortical function during anesthesia andmight qualify the method for monitoring anesthesia inhumans.

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