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In Vitro Evaluation of Leishmanicidal Properties of a New Family of Monodimensional Coordination Polymers Based on Diclofenac Ligand

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Document pages: 13 pages

Abstract: A series of isostructural chains with general formula [M(diclof) 2 (H 2 O) 2 ]·(EtOH) 2 have been obtained from reactions between diclofenac ligand ( diclof ) and first row transition nitrates (M = Mn (1) , Ni (2) and Co (3) ). These monodimensional coordination polymers have been characterized and their crystal structures have been solved by X-ray diffraction methods, elucidating isostructural compounds are chains in which water molecules bridge between the different metallic centers, while the diclofenac ligands are coordinated to the octahedral coordination environment of the same. Magnetic studies of these complexes have revealed the existence of moderate ferromagnetic interactions among the manganese, nickel and cobalt ions, with J values of 0.1, 0.60 and 3.3 cm −1 , respectively. It must be highlighted that the in vitro leishmanicidal activity of these new complexes has been studied against three different strains of Leishmania spp. showing a higher efficacy than the reference drug Glucantime, demonstrating the potential of these novel materials based on coordination chemistry.

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