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Synthesis and antibacterial activity of 1-(-4-Methyl Phenyl) -2-(3-Bromo Phenyl) -4- (4-substituted benzylidene) -5-imidazolones

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Document pages: 5 pages

Abstract: The proposed work involves synthesis of some new imidzolones from bromo substituted oxazolones in presence of zeolite as a catalyst. The bromo substituted oxazolones in turn were obtained from bromo benzoyl glycine and variedly substituted aromatic aldehydes in presence of acetic anhydride and anhydrous sodium acetate. The eight variedly substituted compounds were prepared by this method. Reflux time in the synthesis of 5-imidazolones was significantly reduced by employing Zeolite as a catalyst. The characterisation of these compounds was made by chemical properties, elemental analysis as well as spectral analysis (like IR,1H-NMR). The synthesized compounds were screened for antimicrobial activity against the test organisms E.coli, S.typhi, P.vulgaris, B.subtilis, S.aurus and S.pneumoniae. The compounds containing -OCH3,-N(CH3)2,-NO2 and -OH group showed maximum activity against S.typhi B.subtilis and E.coli pathogens.

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