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Fatty Acid Derivative of Methanol Extract of Oldenlandia corymbosa: A Potential Compound against K. pneuminiae and MCF-cell Lines

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Document pages: 7 pages

Abstract: The acceptance of medicinal plants is increasing progressively for treating human diseases. The phytochemical components; bioactive chemicals present in the plants have a property to protect human body from disease causing agents. The aim of the present study is to screen the methanol extracted fatty acid derivative of Oldenlandia corymbosa by GC-MS and to evaluate its anti oxidant, anti bacterial and anti cancer potential. Plants were collected and extracted with Soxhlet apparatus and the extract was subjected for compound separation by column chromatography. Separated compound from plant was subjected to antioxidant, anti bacterial and anticancer study. GC-MS analysis of the compound was done using standard protocol. Methanol fraction of the O.corymbosa showed antibacterial property on K.pneumoniaea only and it has no effect on E. coli, S. typhi and S. aureus. Disc diffusion results revealed that the methanol fraction has effect only on K.pneumoniae with zone of inhibition 16mm. In our study the methanol fraction showed maximum antioxidant property. IC50 value was found to be 0.38±0.004 mg ml. The result shows that there is a concentration and time dependent increase in the percentage of cytotoxicity induced by the compound. The highest anticancer activity on MCF-7 cell line observed with IC50 value of 0.27±0.18 mg ml. GC-MS study of the Methanol fraction has showed number of phytoconstituents which contribute to the medicinal property of compound. The major constituents present in the compound is methyl stearate (16.62 ), Methyl plamitate (14.53 ), 1,2-Bezenedicarboxilicacid (6.61 ), Trans2-Nonadecene (5.44 ) etc. It is only a preliminary study of the anti bacterial and anticancer property of Methanol fraction, an in depth study will provide a good concrete base for pharmacological activity of compound.

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