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Formulation and In-Vitro Dissolution Enhancement of Blonanserin Using Liquisolid Compacts

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Document pages: 19 pages

Abstract: The present study was to carried out pre-formulation studies for possible drug and excipients interactions and to formulate liquid solid complex using different carriers and disintegrants and to identify Physico-chemical characterization and In vitro drug release study of prepared liquid solid complex. The solubility studies of Blonanserin in presence of PEG were high when compared with Propylene Glycol and glycerine. The liquisolid technique was found to be a promising approach for improving the dissolution of poorly soluble drugs like Blonanserin. The Dissolution of Blonanserin was significantly increased in liquisolid Formulation compared to the marketed product. The IR spectra indicate there was no interaction between the drug and excipients. The increased dissolution rate may be due to increased wetting and increased surface area of the particles. From the XRD, FT-IR, Drug content & In Vitro dissolution studies of Blonanserin liquisolid compacts it was concluded that the formulation F9 is the best formulation. The powder blend was subjected to various physical characteristics such as bulk density, tapped density, Hausner’s ratio, compressibility index. The powder was compressed and the core tablets were evaluated for weight variation, hardness, disintegration time, drug content, dissolution studies, powder analysis like XRD and FT-IR studies is concluded the best formulation is F9.

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