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Rose and In-vitro Inhibition of SARS-CoV-2 spike: ACE-2 Interaction

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Document pages: 10 pages

Abstract: The study was performed to evaluate the novel potentials of red rose extract to inhibit SARS-CoV-2 spike protein-Ace2 receptor interaction in vitro. ACE2 receptors were His-labelled, and the interaction was studied by chemiluminescence after the addition of anti-His HRP and HRP substrate. The inhibition of SARS-CoV-2 and ACE2 was seen in a dose-dependent sequence. The 50 inhibitory concentration was observed at 0.75 percent v v of the rose extract, and the 90 inhibition was seen at about 1.8 percent v v. Steam inhalation or nebulization could be simple methods of delivering rose extract to the lower respiratory tract and pulmonary tissues. There is a potential for the rose extract to inhibit SARS-CoV-2 and ACE2 receptor inhibition in-vitro, which could have beneficial effects in Covid-19 treatment. Further tests need to be performed to study the therapeutic benefits in vivo.

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