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Inflamed Host: Serine/Threonine Phosphorylation Signaling Pathway that Links Obesity and Insulin Resistance and Worse Prognosis for COVID-19

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Document pages: 12 pages

Abstract: An outbreak of pneumonia and acute respiratory syndrome, caused by a novel coronavirus (SARS-CoV2) and known as coronavirus disease 2019 (COVID-19) emerged in Wuhan, China in December 2019 as a highly contagious coronavirus and spread through worldwide. Meantime, the mortality rate following infection seems to be worst in certain groups of people with comorbidities like obesity, hypertension, insulin resistance, diabetes, cancer and other immunodeficiencies. After all, what and why these diseases seems to aggravate SARS-CoV2 infection? The insulin resistance mechanism shows upper activity e hyperphosphorylation Ser Thr residues. Its could be assumed that the higher serine availability in diabetic or insulin resistance conditions could increase the TMPRSS2 activity and consequently increase viral replication in the host. This would help to further elucidate why patients with metabolic syndrome, obesity and diabetes, worsen more than others.

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