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In-Host Analysis of Malaria Dynamics in Humans

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Document pages: 19 pages

Abstract: Humanmalaria infection poses a major global health threat worldwide. Yet, nosophisticated mathematical model exists to study the complex dynamics and interactions between the parasites andhost immune response at the blood and liver stages. In this paper, an in-hostmathematical model of Plasmodium falciparum malaria dynamics and interactionsin an infected host cells are studied at the liver stage by incorporating thered blood cells and the immune system. Numerical simulations are applied toinvestigate the interactions between the host immune response, the parasitedynamics, and the disease dynamics at both the blood and liver stages. Resultsshow that immunity has asignificant impact in clearing infected red blood cells. Furthermore, theinfected erythrocytes and hence the severity of malaria tend to increase withincreasing density of merozoites in the blood. The result revealed thatintervention during malaria infection should focus on minimizing merozoiteinvasion rate on healthy erythrocytes and the density of merozoites incirculation.

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