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Novel Acidic ChCI/TFA DES as Reaction Medium and Catalyst for Biginelli and Hantzsch Reactions

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Document pages: 19 pages

Abstract: Novel deep eutectic solvent (DES) using Choline Chloride (ChCl) as the hydrogen bond acceptor and triflouroacetic acid (TFA) as hydrogen bond donor (1.0:1.5 molar ratio) was prepared at room temperature and characterized by FT- IR and 1H NMR spectroscopy. Also, this novel acidic RTDES (room temperature deep eutectic solvent) was successfully used both as reaction medium and catalyst in Biginelli, Biginelli-like, and Hantzsch reactions. The procedures have the advantages of high yields, short reaction times and easy work-up as well as the reaction conditions are relatively mild and don t require additional catalysts and organic solvents. The DES could be easily recycled without considerable loss of activity even after three cycles.

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