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Magnetic Mesoporous Embolic Microspheres in Transcatheter Arterial Chemoembolization for Liver Cancer

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Document pages: 36 pages

Abstract: Transcatheter arterial chemoembolization (TACE) is the main treatment for liver cancer. Although many embolic agents have been exploited in TACE, embolic agents combining embolization, drug-loading, and imaging properties have not yet been constructed. Herein, we report a new magnetic mesoporous embolic microsphere that can simultaneously be loaded with doxorubicin (Dox), block vessels and be observed by magnetic resonance imaging (MRI). The microspheres are prepared by decorating magnetic polystyrene Fe3O4 particles with mesoporous organosilica microparticles (denoted as PS Fe3O4@MONs). The PS Fe3O4@MONs are uniformly spherical, large (50 μm), have a high specific surface area and uniform mesopores, and exhibit an excellent drug-loading capacity for Dox (460.8 μg mg-1). Dox-loaded PS Fe3O4@MONs (PS Fe3O4@MON@Dox) could effectively inhibit liver cancer cell growth. A VX2 rabbit liver tumor model was constructed to study the efficacy of TACE with PS Fe3O4@MON@Dox. In vivo experiments show that PS Fe3O4@MON@Dox could be smoothly delivered through an arterial catheter to achieve chemoembolization. Moreover, PS Fe3O4@MON@Dox and residual tumor parenchyma could be distinguished by MRI, which is of great significance for evaluating the efficacy of TACE. Histopathology showed that PS Fe3O4@MON@Dox could be deposited in the tumor vessels, completely blocking the blood supply. Overall, PS Fe3O4@MON@Dox show excellent drug-loading, embolization and imaging performance and have great potential in TACE.

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