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New Insights in the Design of Nanoparticles Entrapping Diclofenac

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Document pages: 6 pages

Abstract: Properties resulting from their reduced dimensions, but also because they are promising building blocks for more complex nanostructures. Diclofenac is an anti-inflammatory drug that inhibits cyclooxygenase (COX)-2 enzyme with greater potency than COX-1 does. The adverse effects can occur when NSAIDs are used for a long time, leading to gastrointestinal and renal dysfunctions. Nanoparticles of diclofenac are nanotransporters that facilitate the intracellular penetration and can reduce the side-effects of uncorporated diclofenac. Nanoparticles incorporating diclofenac have been made using various polymers and different stabilizers. The most important parameters in the characterization of nano-systems are the particle size and their size distribution in the colloidal solution, the Zeta potential, the polymorphism, the crystallization level, the degree of drug loading and its release profile.

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