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Enhanced Photoconversion Performance of NdVO 4/Au Nanocrystals for Photothermal/Photoacoustic Imaging Guided and Near Infrared Light-Triggered Anticancer Phototherapy

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Document pages: 41 pages

Abstract: Although neodymium vanadate (NdVO4) has been investigated and applied in some fields owing to its intensive ultraviolet (UV) light absorption, weak absorption in visible (Vis) and near infrared (NIR) regions constrains its environmental remediation and biomedical applications. Herein, plasmonic precious metal Au as light trapping agent is deposited onto NdVO4 to form metal semiconductor hybrid nanostructure for improving the Vis NIR light absorption. NdVO4 Au heterojunction nanocrystals (NCs) were synthesized by NdVO4 nanorods (NRs) and plasmonic Au nanoparticles (NPs), followed by introducing polyvinylpyrrolidone (PVP) to enhance stability and biocompatibility, which exhibit elevated photocatalytic performance for organic dye degradation, photothermal conversion effect as high as 32.15 and cytotoxic reactive oxygen species (ROS) production ability. NdVO4 Au can be internalized efficiently via endocytosis and cause apparent phototoxicity on Hela cells. In vivo experiments further show that NdVO4 Au can act as a high-efficiency NIR light-triggered anticancer agent with excellent tumor inhibition effect. In addition, based on outstanding light-to-heat conversion performance and thermal expansion effect under NIR irradiation, NdVO4 Au provides photothermal (PT) and photoacoustic (PA) dual-modal imaging platform for precise cancer diagnosis and treatment.

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