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Characterization of Chemoelastic Effects in Arteries Using Digital Volume Correlation and Optical Coherence Tomography

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Document pages: 25 pages

Abstract: Understanding stress-strain relationships in arteries is important for fundamental investigations in mechanobiology. Here we demonstrate the essential role of chemoelasticity in determining the mechanical properties of arterial tissues. Uniaxial tensile tests were carried out on samples of porcine aortas immersed in a hyperosmotic solution. The tissue deformations were tracked using optical coherence tomography (OCT) during the tensile tests and digital volume correlation (DVC) was used to obtain measurements of depth-resolved strains across the whole thickness of the tested aortas. The hyperosmotic solution exacerbated chemoelastic effects, and we were able to measure different manifestations of these chemoelastic effects: existence of an osmotic modulus on top of the elastic modulus, swelling of the media inducing a modification of its optical properties, existence of a transverse tensile strain (negative Poisson’s ratio). For the first time ever to our best knowledge, 3D strains induced by these chemoelastic effects in soft tissues were quantified thanks to the OCT-DVC method. Eventually, we proposed a model assuming that chemoelasticity affects only the hydrostatic pressure whereas the deviatoric stress only depends on the hyperelastic contribution of the tissue. Without doubt, chemoelasticity plays an essential role in arterial mechanobiology in vivo and future work should focus on characterizing chemoelastic effects in arterial walls under physiological and disease conditions.

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